Parvalbumin as a Pleomorphic Protein
Parvalbumin, oncomodulin, metal binding, protein unfolding, protein isoforms, structural microheterogeneity, intrinsically disordered protein, antioxidant activity, allergen
Digital Object Identifier (DOI)
Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functionality. This review sums up these findings and discusses their potential physiological significance.
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Citation / Publisher Attribution
Current Protein & Peptide Science, v. 18, issue 8, p. 780-794
Scholar Commons Citation
Permyakov, Eugene; Uversky, Vladimir; and Permyakov, Sergei, "Parvalbumin as a Pleomorphic Protein" (2017). Molecular Medicine Faculty Publications. 326.