Bats Are Natural Reservoirs of SARS-Like Coronaviruses
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Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.
Bats, Natural Reservoirs, Severe Acute Respiratory Syndrome, Coronavirus-Like Virus
Li, Wendong; Shi, Zhengli, Yu, Meng; Ren, Wuze; Smith, Craig; Epstein, Jonathan H.; Wang, Hanzhong; Crameri, Gary; Hu, Zhihong; Zhang, Huajun; Zhang, Jianhong; McEachern, Jennifer; Field, Hume; Daszak, Peter; Eaton, Bryan T.; Zhang, Shuyi; and Wang, Lin-Fa, "Bats Are Natural Reservoirs of SARS-Like Coronaviruses" (2005). KIP Articles. 416.