Title

ORF8-related genetic evidence for Chinese horseshoe bats as the source of human Severe Acute Respiratory Syndrome coronavirus

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Publication Date

February 2016

Abstract

Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.

Keywords

Coronaviruses, SARS (Disease), Horseshoe bats, Asia, China

Type

Article

Notes

Volume 213, Issue 4

Publisher

Oxford University Press

Description

1 online resource

Identifier

K26-05433

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