ORF8-related genetic evidence for Chinese horseshoe bats as the source of human Severe Acute Respiratory Syndrome coronavirus
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Oxford University Press
Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located between the M and N genes. Among unique accessory ORFs, ORF8 is most hypervariable. In this study, the ORF8s of all SL-CoVs were classified into 3 types, and, for the first time, it was found that very few SL-CoVs from Rhinolophus sinicus have ORF8s that are identical to that of human SARS-CoV. This finding provides new genetic evidence for Chinese horseshoe bats as the source of human SARS-CoV.
Volume 213, Issue 4
Coronaviruses, SARS (Disease), Horseshoe bats, Asia, China
1 online resource
Coronaviruses; SARS (Disease); Horseshoe bats
Wu, Zhiqiang; Yang, Li; Ren, Xianwen; Zhang, Junpeng; Yang, Fan; Zhang, Shuyi; and Jin, Qi, "ORF8-related genetic evidence for Chinese horseshoe bats as the source of human Severe Acute Respiratory Syndrome coronavirus" (2016). KIP Articles. 3901.