Title

A high-coverage Neandertal genome from Vindija Cave in Croatia

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Publisher

American Association for the Advancement of Science

Publication Date

November 2017

Abstract

To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.

Notes

Volume 358, Issue 6363 5 p.

Keywords

Genomes, Neanderthals, Caves, Europe, Croatia, Zagreb, Grad, Vindija Cave

Subject: topical

Genomes; Neanderthals; Caves

Subject: geographic

Europe; Croatia; Zagreb, Grad; Vindija Cave

Type

Article

Genre

serial

Identifier

K26-05468

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