Digital Object Identifier (DOI)
Nonhepatosplenic/noncutaneous γδ peripheral T-cell lymphoma (NHNCγδ PTCL) represents a miscellaneous group of unrelated T-cell lymphomas of which only isolated cases have been reported. We describe two cases of transformation from T-lymphoblastic leukemia/lymphoma to NHNCγδ PTCL. Transformation into more aggressive disease is a rare event in T-cell lineage-derived hematologic malignancies compared to B-cell neoplasms. Nevertheless, both of our cases involved relapse as PTCL manifested with skin involvement and an overt shift from blastic morphology to large granular leukemia-like mature T cells. Among other notable molecular characteristics, expression of immature markers such as TdT was lost in both cases. Based on cytogenetics, phenotype, and morphology, both patients represent a novel phenomenon of clonal transformation from T-ALL to PTCL which has rarely been reported in the literature. Such transformation may carry important diagnostic and biological implications.
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Citation / Publisher Attribution
Case Reports in Hematology, v. 2018, art. 9191582
Scholar Commons Citation
Markow, Michael; Mirza, Abu-Sayeef; Perez, Lia; Shao, Haipeng; Horna, Pedro; Anasetti, Claudio; Sokol, Lubomir; and Hussaini, Mohammad O., "Transformation of T-Cell Acute Lymphoblastic Lymphoma to Peripheral T-Cell Lymphoma: A Report of Two Cases" (2018). Internal Medicine Faculty Publications. 123.