Degree Granting Department
College of Pharmacy
Siva Kumar Panguluri, Ph.D.
Manas Biswal, Ph.D.
Jennifer Rodgers, Ph.D.
Hospital mortality, Kv channels, Cardiotoxicity, Ventricular remodeling
Administration of Hyperoxia (>90 % oxygen) is a pervasive intervention to supplement respiratory needs in patients admitted in ICU/critical care units. Current literature suggests that prolonged use of Hyperoxia therapy is directly associated with in-hospital mortality. The exact reason for this high mortality under Hyperoxia is unknown. Recent explorations in Dr. Panguluri lab identified that dysregulation of Kv channels plays a vital role in the pathophysiology of Hyperoxia-induced pulmonary and cardiac complications using animal models. The proposed research will focus on the part of Hyperoxia in generating cardiotoxicity and ventricular remodeling in the type-1 diabetes patients using the Akita, mouse model.
Scholar Commons Citation
Bolleddu, Samuel Ignatious, "Effect of Hyperoxia on Type-1 Diabetic Mouse Model" (2019). Graduate Theses and Dissertations.