Differential Association of Vitronectin and Fibronectin with Glass and Electrospun Fibers of a Poly (D-Lysine) /Poly (Acrylic Acid)

Author

Syed Muhammad Sohaib Zafar Zafar, University of South FloridaFollow

Graduation Year

2016

Document Type

Thesis

Degree

M.S.M.S.E

Degree Name

MS in Materials Science and Engineering (M.S.M.S.E)

Degree Granting Department

Chemical Engineering

Major Professor

Donald Haynie, Ph.D.

Co-Major Professor

Nathan Gallant, Ph.D.

Committee Member

Piyush Koria, Ph.D.

Keywords

Serum Proteins, Integrins, Focal Adhesions

Abstract

Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV₃ integrin which ultimately helps in clot formation.

Scholar Commons Citation

Zafar, Syed Muhammad Sohaib Zafar, "Differential Association of Vitronectin and Fibronectin with Glass and Electrospun Fibers of a Poly (D-Lysine) /Poly (Acrylic Acid)" (2016). USF Tampa Graduate Theses and Dissertations.
https://digitalcommons.usf.edu/etd/6444