Degree Granting Department
Edward Turos, Ph.D.
Julie P. Harmon, Ph.D.
Bill J. Baker, Ph.D.
Kirpal S. Bisht, Ph.D.
β-Lactam, Staphylococcus, Drug delivery, Nanoparticle
N-Thiolated β-lactams represent a novel family of antibacterial agents, whose in vitro activity is confined largely to Staphylococcus species, including multidrug-resistant forms of S. aureus. N-Thiolated β-lactams have recently been shown to possess intriguing biological activities which are addressed in Chapter II. Current development of nanoparticles as a new drug delivery vehicle is described in Chapter III. Chapter IV and V described the current research in our laboratories focusing on the synthesis and characterization of emulsified polyacrylate/polyacrylamide nanoparticle antibacterials for drug delivery of water-insoluble antibiotics. These nanoparticles can be prepared in aqueous media directly from acrylate/acrylamide monomers through free radical microemulsion polymerization. These emulsions contain antibiotic-conjugated polyacrylate nanospheres measuring 30-60 nm in diameter and have enhanced antibacterial activity against drug resistant S. aureus (MRSA) through what we believe is a novel mechanism.
Scholar Commons Citation
Wang, Yang, "Antibiotic-Conjugated Polyacrylate Nanoparticles: New Opportunities for Development of Anti-MRSA Agents" (2006). USF Tampa Graduate Theses and Dissertations.