Cardiovascular Health in Adolescents with Type 1 Diabetes: The SEARCH CVD Study
adolescent, carotid intima-media thickness, diabetes mellitus, type 1, pulse wave analysis
Digital Object Identifier (DOI)
Objective: In their Strategic Impact Goal Statement, the American Heart Association focused on primordial prevention of cardiovascular risk factors by defining metrics for ideal cardiovascular health (ICH). The prevalence of ICH among youth with type 1 diabetes is unknown. Youth with type 1 diabetes face an increased risk of cardiovascular disease (CVD) as they age. The purpose of this report was to examine the prevalence of ICH in a population of youth with type 1 diabetes and to examine the association of ICH with measures of cardiovascular structure and function.
Research design and methods: This report is based on SEARCH CVD an ancillary study to the SEARCH for Diabetes in Youth. A total of 190 adolescents with type 1 diabetes had complete data on all of the ICH metrics at baseline and had measures of arterial stiffness [pulse wave velocity (PWV), brachial distensibility (BrachD), and augmentation index (AIx)] and carotid intima-media thickness completed at a follow-up visit [on average 5 yr after baseline (interquartile range 4–5)].
Results: No subjects met the ICH criteria for all 7 metrics. Meeting an increasing number of ICH metrics was significantly associated with lower arterial stiffness [lower PWV of the trunk (β = −0.02 ±0.01; p = 0.004) and AIx (β = −2.2 ±0.66; p = 0.001), and increased BrachD (β = 0.14 ±0.07; p = 0.04)].
Conclusions: Increasing number of ICH metrics was significantly associated with decreased arterial stiffness, but prevalence of ICH in this population was low. Youth with type 1 diabetes could benefit from improvements in their cardiovascular health.
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Citation / Publisher Attribution
Pediatric Diabetes, v. 15, issue 7, p. 502-510
Scholar Commons Citation
Alman, Amy C.; Talton, Jennifer W.; Wadwa, R Paul; Urbina, Elaine M.; Dolan, Lawrence M.; Daniels, Stephen R.; Hamman, Richard F.; D'Agostino, Ralph B.; Marcovina, Santica M.; Mayer-Davis, Elizabeth J.; and Dabelea, Dana M., "Cardiovascular Health in Adolescents with Type 1 Diabetes: The SEARCH CVD Study" (2014). Epidemiology and Biostatistics Faculty Publications. 34.