Title

The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease

Document Type

Article

Publication Date

2018

Keywords

AD risk, Alzheimer’s disease, amyloid, obstructive sleep apnea, OSA phenotypes

Digital Object Identifier (DOI)

https://doi.org/10.3233/JAD-179936

Abstract

Obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research. OSA is intrinsically associated with disruptions of sleep architecture, intermittent hypoxia and oxidative stress, intrathoracic and hemodynamic changes as well as cardiovascular comorbidities. All of these could increase the risk for AD, rendering OSA as a potential modifiable target for AD prevention. Evidence supporting the relevance of each of these mechanisms for AD risk, as well as a possible effect of AD in OSA expression, will be explored in this review.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Journal of Alzheimer's Disease, v. 64, issue s1, p. S255-S270

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