Synergistic Palladium/enamine Catalysis for Asymmetric Hydrocarbon Functionalization of Unactivated Alkenes with Ketones
Digital Object Identifier (DOI)
Synergistic palladium and enamine catalysis was explored to promote ketone addition to unactivated olefins. A secondary amine-based organocatalyst was identified as the optimal co-catalyst for the directed Pd-catalyzed alkene activation. Furthermore, asymmetric hydrocarbon functionalization of unactivated alkenes was also achieved with good to excellent yield (up to 96% yields) and stereoselectivity (up to 96% ee). This strategy presented an efficient approach to prepare α-branched ketone derivatives under mild conditions.
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Citation / Publisher Attribution
Organic & Biomolecular Chemistry, v. 16, p. 6607-6611
Scholar Commons Citation
Wei, Chiyu; Ye, Xiaohan; Xing, Qingyu; Hu, Yong; Xie, Yan; and Shi, Xiaodong, "Synergistic Palladium/enamine Catalysis for Asymmetric Hydrocarbon Functionalization of Unactivated Alkenes with Ketones" (2019). Chemistry Faculty Publications. 226.