Title

Synergistic Palladium/enamine Catalysis for Asymmetric Hydrocarbon Functionalization of Unactivated Alkenes with Ketones

Document Type

Article

Publication Date

2019

Digital Object Identifier (DOI)

https://doi.org/10.1039/C9OB01165J

Abstract

Synergistic palladium and enamine catalysis was explored to promote ketone addition to unactivated olefins. A secondary amine-based organocatalyst was identified as the optimal co-catalyst for the directed Pd-catalyzed alkene activation. Furthermore, asymmetric hydrocarbon functionalization of unactivated alkenes was also achieved with good to excellent yield (up to 96% yields) and stereoselectivity (up to 96% ee). This strategy presented an efficient approach to prepare α-branched ketone derivatives under mild conditions.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Organic & Biomolecular Chemistry, v. 16, p. 6607-6611

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