Novel Bis-cyclic Guanidines as Potent Membrane-active Antibacterial Agents with Therapeutic Potential
Digital Object Identifier (DOI)
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.
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Citation / Publisher Attribution
Chemical Communication, v. 53, p. 11948-11951
Scholar Commons Citation
Teng, Peng; Nimmagadda, Alekhya; Su, Ma; Hong, Yuzhu; Shen, Ning; Li, Chunpu; Tsai, Ling-Yu; Cao, Jessica; Li, Qi; and Cai, Jianfeng, "Novel Bis-cyclic Guanidines as Potent Membrane-active Antibacterial Agents with Therapeutic Potential" (2017). Chemistry Faculty Publications. 215.