Title

One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles

Document Type

Article

Publication Date

2015

Digital Object Identifier (DOI)

https://doi.org/10.1021/acs.orglett.5b01909

Abstract

A one-pot asymmetric synthesis of 1,2,3,4-tetrahydrocarbazoles has been developed via an enantioselective [3 + 3] annulation of 2-alkynylindoles and donor–acceptor cyclopropanes. In the presence of chiral Lewis acids as catalysts, a series of optically active tetrahydrocarbazoles were furnished in high yields (63–87%) with good to excellent levels of enantioselectivity (up to 94% ee).

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Organic Letters, v. 17, issue 16, p. 4014-4017

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