One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles
Digital Object Identifier (DOI)
A one-pot asymmetric synthesis of 1,2,3,4-tetrahydrocarbazoles has been developed via an enantioselective [3 + 3] annulation of 2-alkynylindoles and donor–acceptor cyclopropanes. In the presence of chiral Lewis acids as catalysts, a series of optically active tetrahydrocarbazoles were furnished in high yields (63–87%) with good to excellent levels of enantioselectivity (up to 94% ee).
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Citation / Publisher Attribution
Organic Letters, v. 17, issue 16, p. 4014-4017
Scholar Commons Citation
Liu, Qiong-Jie; Yan, Wen-Guang; Wang, Lijia; Zhang, X. Peter; and Tang, Yong, "One-Pot Catalytic Asymmetric Synthesis of Tetrahydrocarbazoles" (2015). Chemistry Faculty Publications. 187.