Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: An Immediate Access to Diverse 3-Aryl-4(1H)-Quinolones
Document Type
Article
Publication Date
2015
Digital Object Identifier (DOI)
https://doi.org/10.1021/jo5023958
Abstract
A clean arylation protocol of ethyl acetoacetate was developed using hypervalent diaryliodonium salts under mild and metal-free conditions. The scope of the reaction, using symmetric and unsymmetric iodonium salts with varying sterics and electronics, was examined. Further, this method has been applied for the synthesis of antimalarial compound ELQ-300, which is currently in preclinical development.
Was this content written or created while at USF?
Yes
Citation / Publisher Attribution
The Journal of Organic Chemistry, v. 80, issue 5, p. 2513-2520
Scholar Commons Citation
Monastyrskyi, Andrii; Namelikonda, Niranjan K.; and Manetsch, Roman, "Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: An Immediate Access to Diverse 3-Aryl-4(1H)-Quinolones" (2015). Chemistry Faculty Publications. 161.
https://digitalcommons.usf.edu/chm_facpub/161
