β-Strand Mimics based on Tetrahydropyridazinedione (tpd) Peptide Stitching
Digital Object Identifier (DOI)
Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits.
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Citation / Publisher Attribution
Chemical Communication, v. 51, p. 16259-16262
Scholar Commons Citation
Kang, Chang Won; Sarnowski, Matthew P.; Ranatunga, Sujeewa; Wojtas, Lukasz; Metcalf, Rainer S.; Guida, Wayne C.; and Del Valle, Juan R., "β-Strand Mimics based on Tetrahydropyridazinedione (tpd) Peptide Stitching" (2015). Chemistry Faculty Publications. 154.