Title

β-Strand Mimics based on Tetrahydropyridazinedione (tpd) Peptide Stitching

Document Type

Article

Publication Date

2015

Digital Object Identifier (DOI)

https://doi.org/10.1039/C5CC07189E

Abstract

Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits.

Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

Chemical Communication, v. 51, p. 16259-16262

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