Synthesis, Characterization, and Investigation of the Antimicrobial Activity of Cetylpyridinium Tetrachlorozincate

Authors

Viktor Dubovoy, The State University of New Jersey
Shiri Nawrocki, Rutgers Robert Wood Johnson Medical School
Gaurav Verma, University of South Florida
Lukasz Wojtas, University of South FloridaFollow
Primit Desai, The State University of New Jersey
Hassan Al-Tameemi, The State University of New Jersey
Tatiana V. Brinzari, Colgate-Palmolive Company
Michael Stranick, Colgate-Palmolive Company
Dailin Chen, Colgate-Palmolive Company
Shaopeng Xu, Colgate-Palmolive Company
Shengqian Ma, University of South FloridaFollow
Jeffrey M. Boyd, The State University of New Jersey
Tewodros Asefa, The State University of New Jersey
Long Pan, Colgate-Palmolive Company

Document Type

Article

Publication Date

2020

Digital Object Identifier (DOI)

https://doi.org/10.1021/acsomega.0c00131

Abstract

Cetylpyridinium tetrachlorozincate (referred to herein as (CP)₂ZnCl₄) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C₄₂H₇₆Cl₄N₂Zn with two cetylpyridinium (CP) cations per [ZnCl₄]^2– tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Minimum inhibitory concentration (MIC) of (CP)₂ZnCl₄ was 60, 6, and 6 μg mL^–1 for Salmonella enterica, Staphylococcus aureus, and Streptococcus mutans, respectively. The MIC values of (CP)₂ZnCl₄ were comparable to that of pure cetylpyridinium chloride (CPC), despite the fact that approximately 16% of the bactericidal CPC is replaced with bacteriostatic ZnCl₂ in the structure. A modified layer-by-layer deposition technique was implemented to synthesize mesoporous silica (i.e., SBA-15) loaded with approximately 9.0 wt % CPC and 8.9 wt % Zn.

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Was this content written or created while at USF?

Yes

Citation / Publisher Attribution

ACS Omega, v. 5, issue 18, p. 10359-10365

This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Scholar Commons Citation

Dubovoy, Viktor; Nawrocki, Shiri; Verma, Gaurav; Wojtas, Lukasz; Desai, Primit; Al-Tameemi, Hassan; Brinzari, Tatiana V.; Stranick, Michael; Chen, Dailin; Xu, Shaopeng; Ma, Shengqian; Boyd, Jeffrey M.; Asefa, Tewodros; and Pan, Long, "Synthesis, Characterization, and Investigation of the Antimicrobial Activity of Cetylpyridinium Tetrachlorozincate" (2020). Chemistry Faculty Publications. 109.
https://digitalcommons.usf.edu/chm_facpub/109