WEBVTT 00:00:06.490 --> 00:00:07.090 Hi, 00:00:07.090 --> 00:00:12.040 my name is Navy Bangalore and I am part of the global center for speech 00:00:12.070 --> 00:00:13.270 and hearing research. 00:00:14.230 --> 00:00:18.490 Our research focuses on the issue of presbycusis or 00:00:18.640 --> 00:00:23.530 age-related hearing loss and affects one in three people from the 00:00:23.530 --> 00:00:25.990 ages of 63 to 75. 00:00:26.950 --> 00:00:31.810 Currently there is no known cure for uses only the instruments 00:00:31.810 --> 00:00:36.520 that can help with the symptoms such as hearing aids, inflammation, 00:00:36.520 --> 00:00:41.020 and cochlear, oxidative stress have been linked to age-related hearing loss. 00:00:41.410 --> 00:00:46.180 So we decided to look into an antioxidant and anti-inflammatory amino 00:00:46.180 --> 00:00:50.560 acid or about dine-in to see if it will slow down or prevent the 00:00:50.560 --> 00:00:53.950 degradation of the cochlea, which in turn prevents, 00:00:53.980 --> 00:00:58.690 age-related hearing loss for a little background information or go 00:00:58.700 --> 00:01:03.670 dining has many therapeutic uses as shown here in figure three. 00:01:06.980 --> 00:01:11.600 It is a natural compound that can be easily acquired in our diets through foods 00:01:11.630 --> 00:01:13.490 such as mushrooms and beans. 00:01:14.690 --> 00:01:17.090 Over the course of six months, 00:01:17.540 --> 00:01:21.920 we measured the mice's hearing using an auditory brainstem 00:01:21.920 --> 00:01:22.753 response 00:01:26.030 --> 00:01:30.650 Figure four shows the results for the ABR threshold readings for the 00:01:30.650 --> 00:01:35.630 control, low dose and high dose groups for male and female mice. 00:01:37.310 --> 00:01:41.150 Age-related hearing loss is shown through a gradual elevation of these 00:01:41.150 --> 00:01:44.690 thresholds and for the treated male mice, 00:01:44.900 --> 00:01:49.850 the thresholds stayed relatively same indicating that 00:01:49.850 --> 00:01:51.920 there was no hearing loss occurring. 00:01:52.850 --> 00:01:57.290 The year five shows the amplitudes of the first peaks in the male nights. 00:01:58.250 --> 00:02:03.200 The first peak readings showed the low dose males had better hearing because 00:02:03.200 --> 00:02:04.610 of the higher amplitudes. 00:02:05.420 --> 00:02:09.740 The first peak of an ABR reflects the response of the cochlear nerve 00:02:10.310 --> 00:02:14.870 and the high amplitudes can conclude that the cochlear nerve health was impacted 00:02:14.900 --> 00:02:19.880 and improved based on these results or go dining has 00:02:19.880 --> 00:02:23.180 shown promising potential to be used as a therapeutic drug. 00:02:23.990 --> 00:02:27.500 Thank you so much for listening to this presentation. Goodbye.