Prevalence of Selected Birth Defects by Maternal Nativity Status, United States, 1999–2007
birth defects, epidemiology, nativity, population health, race/ethnicity
Digital Object Identifier (DOI)
Objectives: We investigated differences in prevalence of major birth defects by maternal nativity within racial/ethnic groups for 27 major birth defects.
Methods: Data from 11 population-based birth defects surveillance systems in the United States including almost 13 million live births (approximately a third of U.S. births) during 1999–2007 were pooled. We calculated prevalence estimates for each birth defect for five racial/ethnic groups. Using Poisson regression, crude and adjusted prevalence ratios (aPRs) were also calculated using births to US-born mothers as the referent group in each racial/ethnic group.
Results: Approximately 20% of case mothers and 26% of all mothers were foreign-born. Elevated aPRs for infants with foreign-born mothers were found for spina bifida and trisomy 13, 18, and 21, while lower prevalence patterns were found for pyloric stenosis, gastroschisis, and hypospadias.
Conclusions: This study demonstrates that birth defects prevalence varies by nativity within race/ethnic groups, with elevated prevalence ratios for some specific conditions and lower prevalence for others. More detailed analyses focusing on a broader range of maternal behaviors and characteristics are required to fully understand the implications of our findings.
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Citation / Publisher Attribution
Birth Defects Research, v. 111, issue 11, p. 630-639
Scholar Commons Citation
Kirby, Russell S.; Mai, Cara T.; Wingate, Martha S.; Janevic, Teresa; Copeland, Glenn E.; Flood, Timothy J.; Isenburg, Jennifer; and Canfield, Mark A., "Prevalence of Selected Birth Defects by Maternal Nativity Status, United States, 1999–2007" (2019). Community and Family Health Faculty Publications. 60.